One infant (1.6%) met all three AAP guideline criteria of being DAT-positive, bilirubin within 3 of exchange level, and rising bilirubin despite intensive phototherapy. Understanding why a pediatrician documents a finding enables you to determine if it should be coded. According to available guidelines, inpatient treatment may be considered medically necessary for healthy full-term infants who present with aTSB greater than or equal to 20 mg/dL in the first post-natal week. For most newborns, hematomas from the birth process resolve spontaneously. The authors concluded that limited low-quality evidence indicated that probiotic supplementation may reduce the duration of phototherapy in neonates with jaundice. For more information about blocked lacrimal ducts, visit: aao.org/eye-health/diseases/treatment-blocked-tear-duct. } This review included total of 10 RCTs (2 in preterm neonates and 8in term neonates) that fulfilled inclusion criteria. CETS 99-6 RE. When the newborn is critically ill or injured, codes exist for reporting of services provided during interfacility transport, initial critical care, and subsequent critical services. One study reported a significant reduction in the risk of hyperbilirubinemia and rate of treatment with phototherapy associated with enteral supplementation with prebiotics (RR 0.75, 95 % CI: 0.58 to 0.97; 1 study, 50 infants; low-quality evidence). Metalloporphyrins in the management of neonatal hyperbilirubinemia. This is caused by a small opening in the abdominal muscles that abdominal contents (e.g., fluid, abdominal lining) spill through. A total of 9 RCTs (prophylactic: 6 trials, n=1,761; therapeutic: 3 trials, n=279) with low- to high-risk of bias were included. Montreal, QC: CETS; October 2000. Usually, the nurses pin the sleeve of the affected arm to the body of the newborns t-shirt. Toggle navigation. The SLCO1B1 521 T>C mutation showed a low risk of neonatal hyperbilirubinemia in Chinese neonates, while no significant associations were found in Brazilian, white, Asian, Thai, and Malaysian neonates. Cochrane Database Syst Rev. Additional citations were identified from the bibliography of selected articles and from the abstracts of conference proceedings. Second, according to Cochrane risk of bias estimation, randomized allocation of participants was mentioned in 9 trials. These investigators conducted a systematic review and meta-analysis to examine the safety and efficacy of zinc sulfate on hyperbilirubinemia among neonates. Therefore, well-designed, large randomized, double blind, placebo-controlled trials would be needed to further confirm the efficacy of probiotics. A randomized, triple-blind, placebo-controlled trial of prophylactic oral phenobarbital to reduce the need for phototherapy in G6PD-deficient neonates. Chawla D, Parmar V. Phenobarbitone for prevention and treatment of unconjugated hyperbilirubinemia in preterm neonates: A systematic review and meta-analysis. In a systematic review and meta-analysis, Chu and colleagues (2021) examined if intermittent phototherapy is more effective than continuous phototherapy in the treatment of neonatal hyperbilirubinemia. list-style-type: lower-alpha; Waltham, MA: UpToDate;reviewed January 2015; January 2017. Arch Dis Child Fetal Neonatal Ed. Halliday HL, Ehrenkranz RA, Doyle LW. Toward understanding kernicterus: A challenge to improve the management of jaundiced newborns. So, it was hard for these investigators to determine whether the allocation scheme was appropriate and whether blinding of participants and personnel was implemented. No association was found between the UGT1A1*28 allele and extreme hyperbilirubinemia. For more information about congenital hydrocele, visit: www.webmd.com/parenting/baby/tc/congenital-hydrocele-topic-overview#1. 5 star restaurants st louis. The pooled estimates of correlation coefficients (r) during phototherapy were: covered sites 0.71 (95 % CI: 0.64 to 0.77, 11 studies), uncovered sites 0.65 (95 % CI: 0.55 to 0.74), 8 studies), forehead 0.70 (95 % CI: 0.64 to 0.75, 12 studies) and sternum 0.64 (95 % CI: 0.43 to 0.77, 5 studies). The fetal blood is designed to attract oxygen from the mothers blood. The correlation coefficient improved marginally in the post-phototherapy phase (r = 0.72, 95 % CI: 0.64 to 0.78, 4 studies). registered for member area and forum access. Code 99391 may be reported with diagnosis code Z00.129 (encounter for routine child health examination without abnormal findings) for this service. Reference No. UpToDate[online serial]. Secondary outcomes included incidence of jaundice, TSB level at 24, 48, 72, 96hours, and day 7, duration of hospital stay, and adverse effects (e.g., probiotic sepsis). 2002;3(1). TcB should not be used in patients undergoing phototherapy.". Privacy Policy | Terms & Conditions | Contact Us. at the end of this policy for important regulatory and legal information. Coding Guidelines 18, 19 The third trimester is the time of rapid weight gain, development of muscle mass and fat stores for the newborn. CPT-4 codes: 59400: Antepartum, intrapartum, and postpartum patient care 59400: SG facility fees for the birth center 99460 or 99463: Initial newborn care in a birth center 99461: Second home visit for newborn care Hospital transfer during labor with no postpartum or newborn services Maisels MJ, McDonagh AF. Newborn Care 1. Newborn jaundice happens when the newborns liver and sunshine on the newborns skin dont remove the fetal blood components in an efficient manner. 2020;59(6):588-595. Evaluation and treatment of jaundice in the term infant: A kinder, gentler approach. display: block; Watchko JF, Lin Z. solute carrier organic anion transporter polypeptide 1B1 (SLCO1B1)] may interact with each other and/or environmental contributors to produce significant hyperbilirubinemia. 2017;8:432. on Watchful Waiting:Collecting Newborn Information, Watchful Waiting:Collecting Newborn Information, Tech & Innovation in Healthcare eNewsletter, Capture Active Duty Diagnoses with DoD Unique Codes, Finally Tobacco Use That Isn't a Mental Health Issue, Know Your Payer to Make the Most of Modifier 24, Modifier 25 for E/M on the Day of an Injection Procedure. This study compared oral zinc with placebo. [Phototherapy of newborn infants] - PubMed newborn, known as hyperbilirubenemia. In pre-planned subgroup analyses, the rates of death were 13 % with aggressive phototherapy and 14 % with conservative phototherapy for infants with a birth weight of 751 to 1,000 g and 39 % and 34 %, respectively (relative risk, 1.13; 95 % CI: 0.96 to 1.34), for infants with a birth weight of 501 to 750 g. The authors concluded that aggressive phototherapy did not significantly reduce the rate of death or neurodevelopmental impairment. J Perinatol. The condition affects 3 percent of term male infants, and 1 percent of male infants at one year. 1986;25(6):291-294. Indirect evidence from 3 descriptive uncontrolled studies suggested favorable associations between initiation of screening and decrease in hyperbilirubinemia rates, and rates of treatment or re-admissions for hyperbilirubinemia compared with the baseline of no screening. 1995;96(4 Pt 1):727-729. Neonatal Hyperbilirubinemia - Medical Clinical Policy Bulletins | Aetna Seven (2 prospective) studies evaluated the ability of risk factors (n = 3), early TSB (n = 3), TcB (n = 2), or combinations of risk factors and early TSB (n = 1) to predict hyperbilirubinemia (typically TSBgreater than 95th hour-specific percentile 24 hours to 30 days post-partum). Do I Use 25 or 59 for Same-day Assessment and E/M? In particular, polymorphisms across 3 genes involved in bilirubin production and metabolism: Variant gene co-expression including compound and synergistic heterozygosity enhances hyperbilirubinemia risk, contributing to the etiologic heterogeneity and complex nature of neonatal jaundice. More commonly seen in the documentation are: Without a diagnosis, abnormal results of routine screenings should not be coded unless the pediatrician states the abnormal results have implications for future healthcare. Aetna considers transcutaneous bilirubin devices for evaluating hyperbilirubinemia in term and near-term infants while undergoing phototherapy experimental and investigational becasue this approach is not reliable in infantsin this setting. I have a provider that ordered phototherapy for a newborn in the hospital with jaundice and he is wanting to bill 96900. } Treatment of unconjugated hyperbilirubinemia in term and late preterm infants. Incidence of hyperbilirubinaemia, defined as serum total bilirubin (STB) greater than or equal to 15 mg/dL, was similar between groups (n = 286; risk ratio (RR) 0.94, 95 % CI: 0.58 to 1.52). This review included 6 RCTs that fulfilled inclusion criteria. Waltham, MA: UpToDate;reviewed January 2016. } 1990;10(4):435-438. Do not code the condition as part of the newborn hospitalization unless it requires a consult, diagnostic or therapeutic services, prolonged length of stay, increased nursing services, or there is documentation by the provider for future healthcare needs. J Fam Pract. 3. 92586 Auditory evoked potentials for evoked response audiometry and/or testing of the central nervous system, limited Compared with hospital-based phototherapy, home-based phototherapy appeared more effective for the treatment of neonatal hyperbilirubinemia in reducing the rate of total serum bilirubin (standard mean difference [SMD] = 0.32, 95 % CI: -0.22 to 0.86, p = 0.04); however, there was no signicant difference in duration of phototherapy (SMD = 0.59, 95 % CI: 0.28 to 0.90, p = 0.06) in the 2 groups. These researchers evaluated the role of massage therapy for reduction of NNH in both term and preterm neonates. Children | Free Full-Text | Evaluation of Intravenous Immunoglobulin 1992;89:809-818. 1992;89:822-823. Some watchful waiting issues require continued outpatient evaluation until resolution. Saunders Co.; 2000:513-519. } Severe hyperbilirubinemia was used as a surrogate for possible chronic bilirubin encephalopathy (CBE), because no studies directly evaluated the latter as an outcome. The following are general age-in-hours specifictotal serum bilirubin (TSB)threshold values for phototherapy based upon gestational age and the presence or absence of risk factors (isoimmune hemolytic disease, glucose-6-phosphate dehydrogenase [G6PD] deficiency, asphyxia, significant lethargy, temperature instability, sepsis, acidosis, or albumin of less than 3.0 g/dL [if measured]): Footnotes* Low Risk: 38 weeks gestation and without risk factors; Medium Risk: 38 weeks gestation with risk factors or 35 to 37 6/7 weeks gestation without risk factors; High Risk: 35 to 37 6/7 weeks gestation with risk factors. Studies were analyzed for methodological quality in a "Risk of bias" table. 2001;108(1):175-177. A fetus blood is different than an adults. The ICD-10-PCS code for light treatment of the skin is 6A600ZZ Phototherapy of skin, single for a single treatment. An example is hemangiomas (e.g., strawberry hemangiomas), which do not impinge on vital structures and are not located in the periorbital area, lip, neck, or sacral region. Do not use S42.0- Fracture of clavicle for the initial encounter or subsequent professional encounters. 2013;162(3):477-482. Murki S, Dutta S, Narang A, et al. Sometimes issues heal without interventions, such as minor hematomas from the birth process and laceration from the fetal monitoring electrode. The G6PD 1388 G>A, SLCO1B1 rs4149056 and BLVRA rs699512 SNPs had a significant impact on STB levels. Aetna considers the use of metalloporphyrins (e.g., stannsoporfin (tin mesoporphyrin), Stanate, WellSpring Pharmaceutical Corporation, Neptune, NJ) for the treatment of neonatal jaundice experimental and investigational because their safety and effectiveness for this indication has not been established. Procedures included in the services represented by code 99477 include those listed for the Critical Care Services subsection of CPT (codes 99291 and 99292), as well as additional procedures listed in the Inpatient Neonatal and Pediatric Critical Care subsection (codes 99468-99476, 99466-99467). Petersen and colleagues (2014) stated that extreme hyperbilirubinemia (plasma bilirubin greater than or equal to 24.5 mg/dL) is an important risk factor for severe bilirubin encephalopathy. Phototherapy was started at an average of 7 h of age, and the first IVIG dose was administered at an average of 13 h of life; nearly 25% received a second IVIG dose. Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy. In a Cochrane review on early (less than8 days) postnatal corticosteroid treatmentfor preventing chronic lung disease in preterm infants, Halliday et al(2010) concluded that the benefits of early postnatal corticosteroid treatment, especially DXM, may not out-weigh the known or potential adverse effects of this treatment. Morris BH, Oh W, Tyson JE, et al; NICHD Neonatal Research Network. Home Birth Coding Examples | Kaiser Permanente Washington li.bullet { Honar et al (2016) found that ursodiol added at the time of phototherapy initiation showed a significant reduction in peak bilirubin levels and duration of phototherapy in term infants with unconjugated hyperbilirubinemia without any adverse effects. The authors concluded that the role of massage therapy in the management of NNH was supported by the current evidence. Analysis of rebound and indications for discontinuing phototherapy. Reference Number: CP.MP.150 Coding Implications Date of Last Revision: 10/22 Revision Log See Important Reminder at the end of this policy for important regulatory and legal information. 1992;31(6):345-352. J Matern Fetal Neonatal Med. www.stanfordchildrens.org/en/topic/default?id=developmental-dysplasia-of-the-hip-ddh-90-P02755 hip dysplasia The influence of zinc sulfate on neonatal jaundice: A systematic review and meta-analysis. Aggressive phototherapy, as compared with conservative phototherapy, significantly reduced the mean peak serum bilirubin level (7.0 versus 9.8 mg/dL [120 versus 168 micromol/L], p < 0.01) but not the rate of the primary outcome (52 % versus 55 %; relative risk, 0.94; 95 % confidence interval [CI]: 0.87 to 1.02; p = 0.15). In an evidence-based review on "Neonatal hyperbilirubinemia", Pace and colleagues (2019) stated that clofibrate, metalloporphyrins, and ursodiol have been examined in the management of unconjugated hyperbilirubinemia as augmentation to phototherapy. Aetna considers the use of antenatal phenobarbital to reduce neonatal jaundice in red cell isoimmunized pregnant women experimental and investigational because its effectiveness has not been established. London, UK: BMJ Publishing Group;November 2006. Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia. Stigma (plural stigmata) is a finding that may indicate an abnormal condition, such as a sacral dimple without a visible floor being stigma for occult spina bifida. The pediatrician will spend time evaluating the condition, and at some point, a code in the Q53 Undescended and ectopic testicle range will be used. J Pediatr. PubMed, Embase, Web of science, EBSCO, Cochrane library databases, Ovid, BMJ database, and CINAHL were systematically searched; RCTs evaluating the effect of zinc sulfate versus placebo on the prevention of jaundice in neonates were included. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. This risk increased significantly in the CC genotype carriers at the rs4149056 locus of the SLCO1B1 gene (OR=2.17, 95 % CI: 1.87 to 2.33), whereas it decreased significantly in individuals carrying the G-allele at the rs699512 locus of the BLVRA gene (adjusted OR=0.84, p= 0.01, 95 % CI: 0.75 to 0.95). Ludwig MA. TcB consistently under-estimated TSB levels significantly. When a baby is born, we all hope he or she can be coded with a 99431 (History and examination of the normal newborn infant, initiation of diagnostic and treatment programs and preparation of hospital records). 2021;16(5):e0251584. Risk of bias was assessed using the QUADAS-2 tool. The following are general age-in-hours specificTSBthreshold values forexchange transfusionbased upon gestational age and the presence or absence of risk factors (isoimmune hemolytic disease, glucose-6-phosphate dehydrogenase [G6PD] deficiency, asphyxia, significant lethargy, temperature instability, sepsis, acidosis, or albumin ofless than 3.0 g/dL [if measured]): Footnotes* Low Risk: 38 weeks gestation and without risk factors; Medium Risk: 38 weeks gestation with risk factors or 35 to 37 6/7 weeks gestation without risk factors; High Risk: 35 to 37 6/7 weeks gestation with risk factors. If the lining closes and the fluid has nowhere to go, its a noncommunicating hydrocele. Jaundice in healthy term neonates: Do we need new action levels or new approaches? color: red The authors stated that this study had several drawbacks. In a Cochrane review, Mishra and colleagues (2015) examined the effect of oral zinc supplementation compared to placebo or no treatment on the incidence of hyperbilirubinaemia in neonates during the first week of life and to evaluate the safety of oral zinc in enrolled neonates. Evidence Centre Evidence Report. The code is valid for the year 2023 for the submission of HIPAA-covered transactions. However, if significant time beyond that typical of the infant preventive service is spent in counseling, physicians may also report a problem-oriented service (99212-99215) with modifier -25 to indicate the significant and separately identifiable services provided on the same date. Ambalavanan N, Carlo WA. The authors concluded that the findings of this study demonstrated that the 388 G>A mutation of the SLCO1B1 gene is a risk factor for developing neonatal hyperbilirubinemia in Chinese neonates, but not in white, Thai, Brazilian, or Malaysian populations; the SLCO1B1 521 T>C mutation provides protection for neonatal hyperbilirubinemia in Chinese neonates, but not in white, Thai, Brazilian, or Malaysian populations. Pediatrics. 2006;117(2):474-485. Yang L, Wu, Wang B, et al. Third, since RCTs of included studies centered in a short observation period and did not follow-up the patients in long-term, the methodological quality of clinical trials with probiotics supplementation therapy for neonatal jaundice needed further improvement. The drug was administered into the mouth of the infant by the plastic measure provided with the bottle or with a spoon. 2017;30(16):1953-1962. In a Cochrane review, Gholitabar et al (2012) examined the safety and effectiveness of clofibrate in combination with phototherapy versus phototherapy alone in unconjugated neonatal hyperbilirubinemia. Trikalinos et al (2009) reviewed the effectiveness of specific screening modalities to prevent neonatal bilirubin encephalopathy. Mean STB levels, mg/dL, at 72 12 hours were comparable in both the groups (n = 286; mean difference (MD) -0.20; 95 % CI: -1.03 to 0.63). Read more Therefore, its functional efficiency is important for your market reputation. Chu and colleagues (2020) stated that phototherapy devices have been found to be an effective method for treating neonatal hyperbilirubinemia. The authors concluded that despite the potential practical advantages of BiliMed, its reduced diagnostic accuracy in comparison with BiliCheck does not justify its use in clinical practice. Data selection and extraction were performed independently by 2 reviewers. Acta Paediatr. Until the lacrimal ducts drain spontaneously, the pediatrician can show the parents a massage technique to use between the bridge of the nose and the inside corner of the affected eye. The authors concluded that this meta-analysis showed that probiotics supplementation therapy was an effective and safe treatment for pathological neonatal jaundice. When the newborn jaundice requires additional resources, the correct diagnosis is usually found under P58 Neonatal jaundice due to other excessive hemolysis or P59 Neonatal jaundice from other and unspecified causes codes. CPT offers 3 coding options for initial encounter with ill newborn 4. Phototherapy and Photochemotherapy (PUVA) for Skin Conditions PDF ACDIS day3-5 track5-9 pres 0517-Rogers-f The authors concluded that intermittent phototherapy appeared to be as effective as continuous phototherapy for the treatment of neonatal hyperbilirubinemia and was safer than continuous phototherapy. PDF Bilirubin Light - Phototherapy - Northwood Inc. 2017:1-9. Usually, hip clicks involve watchful waiting, with the tendons and muscles continuing to develop until the click is no longer felt. During an initial newborn evaluation, watchful waiting conditions are findings that usually resolve without medical intervention in a few weeks to a few years. 1993;32:264-267. Trikalinos TA, Chung M, Lau J, Ip S. Systematic review of screening for bilirubin encephalopathy in neonates. Treatment of jaundice in low birthweight infants. Cincinnati Childrens, umbilical hernia: www.cincinnatichildrens.org/health/u/umbilical-herni, Copyright 2023, AAPC J Pediatr (Rio J). 2023 ICD-10-PCS Procedure Code 6A600ZZ: Phototherapy of Skin, Single It is an option to intervene at lower TSB levels for infants closer to 35 wks and at higher TSB levels for those closer to 37 6/7 wks. According to available guidelines, no further measurement of bilirubin is necessary in most cases. Although inflammation occurs less frequently now than in the past because the medication used has changed, it may occur. Aetna considers zinc supplementation for the prevention of hyperbilirubinaemia experimental and investigational because its effectiveness has not been established. Guidelines for Phototherapy | Newborn Nursery | Stanford Medicine Incidence is as high as 30 percent in premature male neonates. Clin Pediatr (Phila). For more information about cryptorchidism, visit: ncbi.nlm.nih.gov/pubmed/10932966. Each payer can develop its own diagnosis-related group. Wong RJ, Bhutani VK. Although declining the inpatient prophylactic services is not reportable by inpatient hospital coders (because it does not affect the hospitalization), outpatient physician office coders can and should use Z28 Immunization not carried out and under immunization status codes when provider-recommended immunizations are not administered. With time, the lacrimal ducts mature and the membrane covering the nasolacrimal ducts open. The smallest but significant difference between TSB and TcB was found on the lower abdomen. PDF Clinical Policy: Phototherapy for Neonatal Hyperbilirubinemia color: blue!important; Chen Z, Zhang L, Zeng L, et al. 2017:1-10. As a family physician, you may also address needs of the mother during a newborn's encounter (e.g., lactation problems). Treatment effects on the following outcomes were determined: mean change in bilirubin levels, mean duration of treatment with phototherapy, number of exchange transfusions needed, adverse effects of clofibrate, bilirubin encephalopathy and neonatal mortality. Although an undescended testicle usually is described as palpable or impalpable, also get the location, if you can. Pediatrics. Petersen JP, Henriksen TB, Hollegaard MV, et al. To determine if the administration of the anti-infective (e.g., erythromycin) externally to the eye (3E0CX2 Introduction of oxazolidinones into eye, external approach) is coded, check if your hospital has a policy on inpatient procedure collection. The ball at the proximal end of the femur is supposed to fit snuggly into the acetabulum (the cup-shaped depression in the pelvis). The USPSTF concluded that the evidence is insufficient to assess the balance of benefits and harms of screening for hyperbilirubinemia to prevent CBE. Testicles develop in the abdomen. Probiotics supplementation therapy for pathological neonatal jaundice: A systematic review and meta-analysis. JavaScript is disabled. Pediatrics. 7. A total of 5 RCTs involving 645 patients were included in the meta-analysis. Hyperbilirubinemia in the term newborn. When to use normal care, sick care codes for newborns in hospital Phototherapy Coding and Documentation in the Time of Biologics For a better experience, please enable JavaScript in your browser before proceeding. If your newborn is too warm, remove the curtains or cover from around the light set. text-decoration: underline; Policy Home phototherapy is considered reasonable and necessary for a full-term These investigators included trials where neonates with hyperbilirubinemia received either clofibrate in combination with phototherapy or phototherapy alone or placebo in combination with phototherapy. Infants had been treated with DXM (0.25 mg/kg twice-daily at postnatal day 1 and 2) or with placebo (normal saline). color: red!important; So why would you not use one of the codes from 99221-99223 for the first day? 1994;94(4 Pt 1):558-565 (reviewed 2000). Natus Medical Inc. ETCOc - An indicator of elevated hemolysis in neonatal hyperbilirubinemia. In a Cochrane review, these investigators examined if administration of prebiotics reduces the incidence of hyperbilirubinemia among term and pre-term infants compared with enteral supplementation of milk with distilled water/placebo or no supplementation. Normal Newborn visit, initial service 1. Armanian AM, Jahanfar S, Feizi A, et al. Description Use total bilirubin. Home Phototherapy for Hyperbilirubinemia -127 Original - WellCare PubMed, Scopus, Embase, Cochrane library, CBM, CNKI, and Wanfang Data were searched to collect the comparative study of home-based phototherapy versus hospital-based phototherapy for the treatment of neonatal hyperbilirubinemia. Cochrane Database Syst Rev. In most of the trials, Field massage was given; 6 out of 8 trials reported reduction in bilirubin levels in term neonates. TcB measurements obtained on the forehead, sternum, abdomen and covered lower abdomen were statistically compared with the corresponding TSB. Approximately 10 to 20 percent of newborns have an umbilical hernia. A total of 14 studies were identified. Also, no association was found for AB0 incompatible cases. But unless the breech presentation or other malpresentation caused a significant finding for the newborn, do not code it on the inpatient hospital record. Aetna considersphototherapy medically necessary forterm andnear-term infantsaccording to guidelines published by the American Academy of Pediatrics (AAP). Elk Grove Village, IL: AAP; 1997. Watchko and Lin (2010) noted that the potential for genetic variation to modulate neonatal hyperbilirubinemia risk is increasingly being recognized. Management of neonatal hyperbilirubinemia. When the hematoma is extensive or combined with other issues that cause excessive hemolysis, involving additional resources, look to P58 Neonatal jaundice due to other excessive hemolysis. Long-term follow-up studies reported an increased risk of abnormal neurological examination and cerebral palsy. These investigators evaluated the effects of antenatal phenobarbital in red cell isoimmunized pregnancies in reducing the incidence of phototherapy and exchange transfusion for the neonate.
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